Guy Lenaers Selected Research

Optic Atrophy

1/2022	NR2F1 database: 112 variants and 84 patients support refining the clinical synopsis of Bosch-Boonstra-Schaaf optic atrophy syndrome.
8/2021	A ROD-CONE DYSTROPHY IS SYSTEMATICALLY ASSOCIATED TO THE RTN4IP1 RECESSIVE OPTIC ATROPHY.
1/2020	Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy.
1/2019	Next generation sequencing in family with MNGIE syndrome associated to optic atrophy: Novel homozygous POLG mutation in the C-terminal sub-domain leading to mtDNA depletion.
1/2018	Neurologic Phenotypes Associated With Mutations in RTN4IP1 (OPA10) in Children and Young Adults.
1/2015	A novel mutation of AFG3L2 might cause dominant optic atrophy in patients with mild intellectual disability.
2/2008	OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.

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Guy Lenaers Research Topics

Disease

12	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 02/2002
10	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 06/2020 - 11/2005
7	Optic Atrophy 01/2022 - 02/2008
6	Neoplasms (Cancer) 05/2022 - 11/2018
6	Optic Nerve Diseases (Optic Neuropathy) 01/2021 - 02/2008
5	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 01/2021 - 02/2002
5	Hearing Loss (Hearing Impairment) 01/2021 - 03/2012
4	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 10/2010
3	Intellectual Disability (Idiocy) 01/2022 - 01/2015
3	Deafness (Deaf Mutism) 01/2021 - 02/2008
3	Nervous System Diseases (Neurological Disorders) 10/2019 - 01/2018
3	Glaucoma 01/2019 - 01/2018
3	Ganglion Cysts (Ganglion) 10/2017 - 08/2010
2	Testicular Neoplasms (Testicular Cancer) 01/2022 - 01/2021
2	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/2020 - 01/2019
2	Insulin Resistance 01/2019 - 01/2018
2	Atrophy 01/2019 - 02/2015
2	MELAS Syndrome (Syndrome, MELAS) 05/2018 - 01/2017
1	Atherosclerosis 05/2022
1	Breast Neoplasms (Breast Cancer) 11/2021
1	Beta-Hydroxyisobutyryl CoA Deacylase Deficiency 10/2021
1	Chorea (Rheumatic Chorea) 10/2021
1	Infections 10/2021
1	Leigh Disease (Leigh's Disease) 10/2021
1	Dry Eye Syndromes (Dry Eye Syndrome) 10/2021
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2021
1	Retinal Degeneration 01/2021
1	Loeys-Dietz Syndrome 01/2021
1	Carcinogenesis 01/2021
1	Sensation Disorders 01/2021
1	Bone Resorption 11/2020
1	Laminopathies 11/2020
1	Hypertension (High Blood Pressure) 11/2020
1	Hereditary Spastic Paraplegia 06/2020
1	Spinocerebellar ataxia 28 06/2020
1	Macular Degeneration (Age-Related Maculopathy) 02/2020
1	Type 2K Charcot-Marie-Tooth disease 01/2020
1	Premature Aging 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Lactic Acidosis 01/2020
1	Disease Progression 01/2020
1	Vision Disorders (Hemeralopia) 01/2019
1	Visceral myopathy familial external ophthalmoplegia 01/2019
1	Paraplegia (Spastic Paraplegia) 01/2019
1	Muscular Diseases (Myopathy) 01/2019

Drug/Important Bio-Agent (IBA)

13	Mitochondrial DNA (mtDNA)IBA 01/2022 - 02/2008
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2012
8	Dynamins (Dynamin)IBA 10/2019 - 11/2005
7	GTP Phosphohydrolases (GTPases)IBA 10/2019 - 11/2005
4	Mitochondrial Proteins (Mitochondrial Protein)IBA 05/2020 - 02/2002
4	Lactic Acid (Lactate)FDA LinkGeneric 01/2020 - 02/2015
3	Biomarkers (Surrogate Marker)IBA 10/2021 - 07/2015
3	Retinaldehyde (Retinal)IBA 08/2021 - 02/2015
3	Amino Acids FDA Link 01/2018 - 11/2016
2	AntigensIBA 01/2022 - 01/2021
2	Oxidoreductases (Dehydrogenase)IBA 10/2021 - 11/2015
2	Niacinamide (Nicotinamide)FDA LinkGeneric 01/2021 - 01/2019
2	Taurine FDA Link 01/2021 - 01/2019
2	m-AAA proteasesIBA 06/2020 - 01/2015
2	CytokinesIBA 01/2020 - 01/2020
2	ResveratrolIBA 01/2020 - 01/2015
2	SpermineIBA 01/2019 - 01/2018
2	Ketone BodiesIBA 05/2018 - 01/2017
2	PolyaminesIBA 01/2018 - 01/2018
2	SpermidineIBA 01/2018 - 11/2016
2	claudin 14IBA 07/2013 - 07/2013
1	Superoxides (Superoxide)IBA 05/2022
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 05/2022
1	Carrier Proteins (Binding Protein)IBA 05/2022
1	Transcobalamins (Transcobalamin II)IBA 05/2022
1	COUP Transcription Factor IIBA 01/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2021
1	Long Noncoding RNAIBA 11/2021
1	Valine (L-Valine)FDA Link 10/2021
1	Pyruvic Acid (Pyruvate)IBA 10/2021
1	HydrolasesIBA 10/2021
1	Aconitate Hydratase (Aconitase)IBA 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021
1	Glycoproteins (Glycoprotein)IBA 01/2021
1	Myelin P0 Protein (Myelin Protein Zero)IBA 01/2021
1	Riboflavin (Vitamin B2)FDA LinkGeneric 01/2021
1	CarnosineIBA 02/2020
1	N 30IBA 01/2020
1	Macrophage Colony-Stimulating FactorIBA 01/2020
1	Glutathione Transferase (Glutathione S-Transferase)IBA 01/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2020
1	nicotinamide-beta-ribosideIBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	ChemokinesIBA 01/2020
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Thymidine PhosphorylaseIBA 01/2019
1	Galectin 1 (LGALS1)IBA 01/2019
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2019
1	Myelin-Associated GlycoproteinIBA 01/2019
1	Galectins (Galectin)IBA 11/2018

Therapy/Procedure

4	Therapeutics 10/2021 - 01/2017
2	Ketogenic Diet 05/2018 - 01/2017
1	Drug Therapy (Chemotherapy) 11/2021